MOTS-c (Standard Pen) research pen
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Cellular Longevity • Metabolic & Fat Optimization

MOTS-c (Standard Pen)

MOTS-c — mitochondrial-derived peptide for metabolic flexibility.

$104.40$130.50Save 20%
Size

As needed for complete course · 1 pen lasts ~20 days

1
Suggested research dosage
Dose: 2,5 mg on every 5th day. Units: 50 units every 5th day.
Course
Every 5th day as long as needed. Continuous, reassess after 3-6 months.
  • ✓ ≥99% purity (HPLC)
  • ✓ Batch-matched COA
  • ✓ Cold-chain 2–8°C
  • ✓ Tracked delivery
  • ✓ Tamper-evident
  • ✓ EU + US shipping
Overview

What is MOTS-c (Standard Pen)?

MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA. It acts as a mitokine, signaling to skeletal muscle and adipose tissue to enhance insulin sensitivity and fat oxidation — effectively mimicking an exercise / fasting signal.

Each PeptidePen is filled in a controlled cleanroom and sealed with tamper-evident packaging. Batch documentation includes identity confirmation, HPLC purity analysis and concentration verification. Strictly for in-vitro research — not for human or veterinary use.

Research library

Go deeper on MOTS-c (Standard Pen)

A full breakdown of mechanism, clinical findings, dosing references and safety signals — for researchers who want the complete picture.

What is MOTS-c?

MOTS-c is a peptide molecule discovered by Dr. Ping Ling and a team of scientists at the University of Southern California. This peptide is located in the mitochondria, the "energy centers" of our cells.

Continue reading the full research brief

MOTS-c is a relatively new product still under research to fully understand its potential health benefits. However, scientific studies indicate that MOTS-c peptide produces several beneficial effects on the body.

One of the best-known effects of MOTS-c is its role in metabolism regulation. It is considered one of the key molecules responsible for controlling metabolism, leading to improved metabolic processes. Research shows that MOTS-c can enhance glucose tolerance, potentially aiding in diabetes treatment.

A study published in Cell Metabolism demonstrated that participants taking MOTS-c had better muscle function and greater physical endurance compared to a control group, suggesting MOTS-c improves physical endurance and muscle mass. It is also believed that MOTS-c may positively influence cognitive function and sleep quality. Another study published in Nature Communications found that participants receiving MOTS-c had improved cognitive performance and sleep quality.

MOTS-c acts as a signaling molecule that communicates with various cells and organs in the body. It may help reduce chronic inflammation and slow aging, contributing to a healthier and longer life.

Benefits of MOTS-c

As previously mentioned, MOTS-c is a new and innovative peptide, but scientific findings suggest it has several potential health benefits, including:

● Regulation of metabolism and improved metabolic processes — ● Enhanced glucose tolerance to help treat diabetes — ● Increased muscle mass — ● Improved physical endurance — ● Reduction of chronic inflammation and immune system support — ● Better sleep quality — ● Improved cognitive function — ● Enhanced cardiovascular health and reduced cardiovascular disease risk — ● Increased insulin sensitivity — ● Prevention of metabolic diseases such as metabolic syndrome — ● Greater resistance to stress — ● Improved mitochondrial function — ● Lower risk of age-related diseases and prolonged healthy lifespan

Clinical Trials and Results

Although MOTS-c is a new product, numerous clinical trials are underway to evaluate its effectiveness and potential in treating various diseases. Some trial results include:

● In an early trial on mice, those receiving MOTS-c exhibited better metabolism and reduced inflammation compared to controls. — ● A trial published in Nature Communications showed that participants who took MOTS-c for 5 days had better cognitive performance and sleep quality. — ● In a Cell Metabolism study on athletes, those given MOTS-c showed improved muscle function and endurance compared to controls. — ● Trials on diabetic mice, also published in Cell Metabolism, showed that MOTS-c improved blood sugar regulation and led to weight loss.

Dosage and Administration

The proper intake and dosage of MOTS-c depend on individual needs and goals. The typical Suggested Research Protocol is 2.5 mg administered once every 5 days.

● The pen programmer is set to 50 units (1 unit equals 1 programmer division) and apply into the abdominal area or front of the thigh. — ● After application, wait 10 seconds before removing the pen. Rotation of application sites is recommended. — ● One pen contains 200 units of 50 micrograms each. — ● One 10 mg MOTS-c pen lasts about 20 days depending on dosage.

Unit to microgram conversions: — ○ 1 unit = 50 mcg — ○ 5 units = 250 mcg — ○ 10 units = 500 mcg — ○ 20 units = 1 mg — ○ 50 units = 2.5 mg — ○ 60 units = 3 mg

Possible Side Effects

So far, no side effects have been reported from taking MOTS-c peptide, but some may occur especially if high doses or prolonged intake occur. Rarely reported side effects include:

● Headache — ● Nausea — ● Stomach discomfort

MOTS-c is generally considered safe when used at recommended dosages and when avoiding excessive or long-term use.

Research highlights

Why researchers choose MOTS-c (Standard Pen)

  • 01

    Improves insulin sensitivity

  • 02

    Reverses high-fat-diet weight gain in rodents

  • 03

    Enhances mitochondrial fat oxidation

  • 04

    Exercise-mimetic gene expression

Specifications

Specifications

Form

Pre-mixed pen

Purity

≥99% HPLC

Storage

2–8°C

Shipping

Cold-chain

COA

Batch-matched

Stacks well with

Researchers often pair this with

SLU-PP-3325-Amino-1MQNAD+
From order to lab bench

Built for trust at every step

  1. 01

    Place your order

    Select pen size and shipping region at checkout.

  2. 02

    Verify the COA

    Each batch is HPLC-assayed and documented.

  3. 03

    Cold-chain ships

    Insulated, temperature-logged delivery.

  4. 04

    Run your protocol

    Reference dosing and references included.

FAQ

Frequently asked questions

Common questions about MOTS-c (Standard Pen) and PeptidePen orders.

Is MOTS-c (Standard Pen) for human use?+

No. All PeptidePen products are strictly for in-vitro laboratory research. Not intended for human or veterinary use.

How is the COA provided?+

Each pen ships with a batch-matched certificate of analysis. A digital copy is also available on request via your order confirmation.

How is shipping handled?+

Orders ship cold-chain (2–8°C) with insulated packaging, ice packs and a temperature log. Tracked delivery in the US and EU.

Can I order in bulk for my lab?+

Yes. Contact our team for institutional pricing, custom concentrations and recurring shipments.

What's your refund policy?+

Damaged or off-spec pens are replaced free of charge. Contact support within 7 days of delivery.

Ready to run MOTS-c (Standard Pen) in your next study?

Pre-mixed, batch-assayed, cold-chain shipped — order before 2pm for same-day dispatch.

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